PROTACpedia
The search can be performed by various parameters such as Target name, UniProt ID, SMILES substructure or by various details regarding a publication.
Note that it is possible to narrow down the search results by querying several fields simultaneously.

The resulting PROTAC images are color coded: green - E3 binder, red - linker, blue - target binding ligand.
If you find this web server of interest, please also try PRosettaC.
Gene or Target name
UniProt Id
Ligand name
E3 Ligase
E3 Binder
PROTAC SMILES (substructure)
PROTAC Name
Author
Year
Pubmed or Patent number
Curator
Algorithm and overview: Nir London (nir.london@weizmann.ac.il)
Server: Jaime Prilusky (jaime.prilusky@weizmann.ac.il)
7 Representative
+40 Active PROTACs
+11 Inactive PROTACs
 DetailsDC50DmaxSource
< 100 nM> 85 % A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader. Cell Chem Biol. 2018 Jan 18;25(1):88-99.e6. PMID:29129717 DOI:10.1016/j.chembiol.2017.10.005
~ 100 % Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML. Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9. PMID:30595531 DOI:10.1016/j.chembiol.2018.11.006
~ 100 % Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML. Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9. PMID:30595531 DOI:10.1016/j.chembiol.2018.11.006
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. PMID:30802347 DOI:10.1002/anie.201901336
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. PMID:30802347 DOI:10.1002/anie.201901336
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. PMID:30802347 DOI:10.1002/anie.201901336
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. PMID:30802347 DOI:10.1002/anie.201901336
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. PMID:30802347 DOI:10.1002/anie.201901336
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. PMID:30802347 DOI:10.1002/anie.201901336
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. PMID:30802347 DOI:10.1002/anie.201901336
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. PMID:30802347 DOI:10.1002/anie.201901336
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. PMID:30802347 DOI:10.1002/anie.201901336
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. PMID:30802347 DOI:10.1002/anie.201901336
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. PMID:30802347 DOI:10.1002/anie.201901336
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. PMID:30802347 DOI:10.1002/anie.201901336
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. PMID:30802347 DOI:10.1002/anie.201901336
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. PMID:30802347 DOI:10.1002/anie.201901336
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. PMID:30802347 DOI:10.1002/anie.201901336
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58(19):6321-6326. PMID:30802347 DOI:10.1002/anie.201901336
Selective degradation of CDK6 by a palbociclib based PROTAC. Bioorg Med Chem Lett. 2019 Jun 1;29(11):1375-1379. PMID:30935795 DOI:10.1016/j.bmcl.2019.03.035
Selective degradation of CDK6 by a palbociclib based PROTAC. Bioorg Med Chem Lett. 2019 Jun 1;29(11):1375-1379. PMID:30935795 DOI:10.1016/j.bmcl.2019.03.035
Selective degradation of CDK6 by a palbociclib based PROTAC. Bioorg Med Chem Lett. 2019 Jun 1;29(11):1375-1379. PMID:30935795 DOI:10.1016/j.bmcl.2019.03.035
Selective degradation of CDK6 by a palbociclib based PROTAC. Bioorg Med Chem Lett. 2019 Jun 1;29(11):1375-1379. PMID:30935795 DOI:10.1016/j.bmcl.2019.03.035
Selective degradation of CDK6 by a palbociclib based PROTAC. Bioorg Med Chem Lett. 2019 Jun 1;29(11):1375-1379. PMID:30935795 DOI:10.1016/j.bmcl.2019.03.035
= 2.1 nM= 89 % Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
= 1.1 nM Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
= 1.6 nM Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
= 1.7 nM Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
= 5.3 nM Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
= 8.6 nM Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
= 10.6 nM Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
= 24.2 nM Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
= 31 nM Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
= 81.6 nM Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
= 86.8 nM Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
= 129.7 nM Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
= 145.5 nM Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
= 271.9 nM Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. PMID:31330105 DOI:10.1021/acs.jmedchem.9b00871
Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs. Bioorg Med Chem Lett. 2020 May 1;30(9):127106. PMID:32184044 DOI:10.1016/j.bmcl.2020.127106
Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs. Bioorg Med Chem Lett. 2020 May 1;30(9):127106. PMID:32184044 DOI:10.1016/j.bmcl.2020.127106
Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs. Bioorg Med Chem Lett. 2020 May 1;30(9):127106. PMID:32184044 DOI:10.1016/j.bmcl.2020.127106
Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs. Bioorg Med Chem Lett. 2020 May 1;30(9):127106. PMID:32184044 DOI:10.1016/j.bmcl.2020.127106
Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs. Bioorg Med Chem Lett. 2020 May 1;30(9):127106. PMID:32184044 DOI:10.1016/j.bmcl.2020.127106
Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs. Bioorg Med Chem Lett. 2020 May 1;30(9):127106. PMID:32184044 DOI:10.1016/j.bmcl.2020.127106
Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs. Bioorg Med Chem Lett. 2020 May 1;30(9):127106. PMID:32184044 DOI:10.1016/j.bmcl.2020.127106