Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 903.82 Hbond donors: 3 Hbond acceptors: 15 cLogP: 5.11 TPSA: 196.92 SMILES: show COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(CCOCCOCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)c(OC)cc23)c(Cl)cc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLM14, MV4-11 DC50: ~ 100 nM Dmax: ~ 50 % Off-targets reported?: No Comments: IC50 of ligand is inhibitory - data from Selleckchem. EC50 of the lidand is Src-dependent cell proliferation - data from Selleckchem. Contributed by: Ronen Gabizon |
Calculated Values
MW: 1,033.16 Hbond donors: 5 Hbond acceptors: 17 cLogP: 3.96 TPSA: 238.77 SMILES: show Cc1cc(C2CC2)cc2ccn(-c3cccc(-c4cc(Nc5ccc(N6CCN(CCOCCOCCNC(=O)CNc7cccc8c7C(=O)N(C7CCC(=O)NC7=O)C8=O)CC6)cn5)c(=O)n(C)c4)c3CO)c(=O)c12 Linker type: Other Incubation time (hours): 4 Cells: MOLM14 DC50: < 40 nM Dmax: ~ 90 % Off-targets reported?: No Comments: IC50 of ligand is 4 nM (BTK inhibition)/ 0.3 nM (binding). EC50 of ligand is 20-30 nM (B-cell signaling). Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 936.02 Hbond donors: 5 Hbond acceptors: 16 cLogP: 5.20 TPSA: 246.06 SMILES: show CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCOCCOCCOCCNC(=O)CNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)ccc34)cc2)no1 Linker type: PEG Incubation time (hours): 12 Cells: MOLM14, MV4-11 DC50: < 10 nM Dmax: ~ 100 % Off-targets reported?: No; confirmed that AURKA, BTK and PTK2B are not degraded Comments: Dmax is difficult to quantify because AC220 raises FLT3 expression levels. IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines. EC50 of PROTAC was measured on MOLM-14 cell lines. Contributed by: Ronen Gabizon
Calculated Values
MW: 1,004.14 Hbond donors: 5 Hbond acceptors: 17 cLogP: 4.80 TPSA: 243.31 SMILES: show CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCN(CCOCCOCCNC(=O)CNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ccc34)cc2)no1 Linker type: Other Incubation time (hours): 12 Cells: MOLM14, MV4-11 DC50: < 10 nM Dmax: ~ 100 % Off-targets reported?: No; confirmed that AURKA, BTK and PTK2B are not degraded Comments: Dmax is difficult to quantify because AC220 raises FLT3 expression levels. IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines. EC50 of PROTAC was measured on MOLM-14 cell lines. Contributed by: Ronen Gabizon
Calculated Values
MW: 891.96 Hbond donors: 5 Hbond acceptors: 15 cLogP: 5.19 TPSA: 236.83 SMILES: show CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCOCCOCCNC(=O)CNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)ccc34)cc2)no1 Linker type: PEG Incubation time (hours): 12 Cells: MOLM14, MV4-11 Off-targets reported?: No Comments: IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 1,176.32 Hbond donors: 5 Hbond acceptors: 19 cLogP: 4.99 TPSA: 295.91 SMILES: show CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCN(C(=O)CCC(=O)NCCCOCCOCCOCCCNC(=O)COc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ccc34)cc2)no1 Linker type: Other Incubation time (hours): 12 Cells: MOLM14, MV4-11 Off-targets reported?: No Comments: IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines Contributed by: Ronen Gabizon
Calculated Values
MW: 1,134.28 Hbond donors: 5 Hbond acceptors: 19 cLogP: 4.68 TPSA: 278.84 SMILES: show CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCN(CC(=O)NCCCOCCOCCOCCCNC(=O)COc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ccc34)cc2)no1 Linker type: Other Incubation time (hours): 12 Cells: MOLM14, MV4-11 Off-targets reported?: No Comments: IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines Contributed by: Ronen Gabizon
Calculated Values
MW: 1,048.17 Hbond donors: 7 Hbond acceptors: 16 cLogP: 4.09 TPSA: 289.28 SMILES: show CC(C)(C)/C(O)=C/C(=N)N[N+](=O)Nc1ccc(-c2cn3c(n2)sc2cc(OCCN4CCN(C(=O)CCC(=O)NCCCCNC(=O)COc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)ccc23)cc1 Linker type: Other Incubation time (hours): 12 Cells: MOLM14, MV4-11 Off-targets reported?: No Comments: IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines Contributed by: Ronen Gabizon
Calculated Values
MW: 1,058.23 Hbond donors: 5 Hbond acceptors: 16 cLogP: 6.20 TPSA: 251.15 SMILES: show CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCN(CC(=O)NCCCCCCCCNC(=O)COc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ccc34)cc2)no1 Linker type: Other Incubation time (hours): 12 Cells: MOLM14, MV4-11 Off-targets reported?: No Comments: IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines Contributed by: Ronen Gabizon
Calculated Values
MW: 1,002.12 Hbond donors: 5 Hbond acceptors: 16 cLogP: 4.63 TPSA: 251.15 SMILES: show CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCN(CC(=O)NCCCCNC(=O)COc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ccc34)cc2)no1 Linker type: Other Incubation time (hours): 12 Cells: MOLM14, MV4-11 Off-targets reported?: No Comments: IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines Contributed by: Ronen Gabizon
Calculated Values
MW: 1,100.27 Hbond donors: 5 Hbond acceptors: 16 cLogP: 6.50 TPSA: 268.22 SMILES: show CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCN(C(=O)CCC(=O)NCCCCCCCCNC(=O)COc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ccc34)cc2)no1 Linker type: Other Incubation time (hours): 12 Cells: MOLM14, MV4-11 Off-targets reported?: No Comments: IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |
Calculated Values
MW: 931.47 Hbond donors: 5 Hbond acceptors: 16 cLogP: 3.58 TPSA: 233.60 SMILES: show CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl Linker type: Other Incubation time (hours): 4 Cells: MOLT-4, MOLM14 IC50: = 10.3 nM DC50: < 100 nM Dmax: > 85 % Off-targets reported?: INCENP, NDUFAB1, CCNH, CCNK, and IKZF1 Comments: General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity. Contributed by: Ronen Gabizon |