Target: CDK6 Cyclin-dependent kinase 6 Q00534 Homo sapiens

E3 Ligand Binder

E3 ligase: Cereblon
E3 binder: Thalidomide
SMILES: show

O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

Ligand

Ligand Name: Palbociclib
Ligand PDB Id: LQQ
PDB with Ligand: 5L2I
SMILES: show

CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O

Representative PROTAC (Active) name: BSJ-03-204 - status:Reviewed Edit

Calculated Values
MW: 832.92
Hbond donors: 3
Hbond acceptors: 15
cLogP: 3.05
TPSA: 218.13

SMILES: show

O=C(NCCCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O

Linker type: Alkane
Incubation time (hours): 4, 24, 72, 96
Cells: Jurkat; Molt4; Granta-519; Mino; Jeko; Rec1; Maver
IC₅₀: = 26.9 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: Yes
Tested engagement in cells?: No
Off-targets reported?: No

Comments: IC50: 26.9nM/10.4nM for CDK4/CDK6, respectively. Can degrade both CDK4 and CDK6.

Contributed by: Yangwode Jing

E3 Ligand Binder

E3 ligase: Cereblon
E3 binder: Thalidomide
SMILES: show

O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

Ligand

Ligand Name: Abemaciclib
Ligand PDB Id: 6ZV
PDB with Ligand: 5L2S
SMILES: show

CCN(CC1)CCN1CC(C=C2)=CN=C2NC3=NC=C(C(C4=CC(F)=C(N=C5C)C(N5C(C)C)=C4)=N3)F

PROTAC (Active) name: BSJ-01-184 - status:Reviewed Edit

Calculated Values
MW: 862.94
Hbond donors: 4
Hbond acceptors: 14
cLogP: 4.33
TPSA: 199.68

SMILES: show

O=C(NCCCCN1CCN(CC2=CC=C(NC3=NC=C(F)C(C4=CC(F)=C5C(N(C(C)C)C(C)=N5)=C4)=N3)N=C2)CC1)CNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O

Linker type: Alkane
Incubation time (hours): 4
Cells: Jurkat
IC₅₀: = 8.61 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: Yes, can also degrade CDK9

Comments: IC50: 8.61nM/12.5nM for CDK4/CDK6, respectively.

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-01-158 - status:Reviewed Edit

Calculated Values
MW: 805.89
Hbond donors: 3
Hbond acceptors: 13
cLogP: 5.21
TPSA: 170.58

SMILES: show

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCCN4CCN(CC5=CC=C(NC6=NC=C(F)C(C7=CC(F)=C8C(N(C(C)C)C(C)=N8)=C7)=N6)N=C5)CC4)=O

Linker type: Alkane
Incubation time (hours): 4
Cells: Jurkat
IC₅₀: = 8.26 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: Yes, can also degrade CDK9

Comments: IC50: 8.26nM/13.1nM for CDK4/CDK6, respectively.

Contributed by: Yangwode Jing

E3 Ligand Binder

E3 ligase: Cereblon
E3 binder: Thalidomide
SMILES: show

O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

Ligand

Ligand Name: Ribociclib
Ligand PDB Id: 6ZZ
PDB with Ligand: 5L2T
SMILES: show

O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C)C

PROTAC (Active) name: BSJ-01-151 - status:Reviewed Edit

Calculated Values
MW: 821.94
Hbond donors: 3
Hbond acceptors: 15
cLogP: 3.06
TPSA: 196.46

SMILES: show

O=C(C1=CC2=CN=C(NC3=NC=C(N4CCN(CCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)CC4)C=C3)N=C2N1C8CCCC8)N(C)C

Linker type: PEG
Incubation time (hours): 4
Cells: Jurkat
IC₅₀: = 175 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No

Comments: IC50: 175nM/142nM for CDK4/CDK6, respectively.

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-01-152 - status:Reviewed Edit

Calculated Values
MW: 761.89
Hbond donors: 3
Hbond acceptors: 13
cLogP: 3.80
TPSA: 178.00

SMILES: show

O=C(C1=CC2=CN=C(N([H])C3=NC=C(N4CCN(CCCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)CC4)C=C3)N=C2N1C8CCCC8)N(C)C

Linker type: Alkane
Incubation time (hours): 4
Cells: Jurkat
IC₅₀: = 79.7 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No

Comments: IC50: 79.7nM/65.5nM for CDK4/CDK6, respectively.

Contributed by: Yangwode Jing

E3 Ligand Binder

E3 ligase: Cereblon
E3 binder: Thalidomide
SMILES: show

O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

Ligand

Ligand Name: Palbociclib
Ligand PDB Id: LQQ
PDB with Ligand: 5L2I
SMILES: show

CC(C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O)=O

Representative PROTAC (Active) name: BSJ-02-162 - status:Reviewed Edit

Calculated Values
MW: 832.92
Hbond donors: 3
Hbond acceptors: 15
cLogP: 3.05
TPSA: 218.13

SMILES: show

O=C(NCCCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O

Linker type: Alkane
Incubation time (hours): 4, 24, 72, 96
Cells: Jurkat; Molt4; Granta-519; Mino; Jeko; Rec1; Maver
IC₅₀: = 25.7 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: Yes
Tested engagement in cells?: No
Off-targets reported?: Yes, can also degrade IKZF1/3

Comments: IC50: 25.7nM/7.57nM for CDK4/CDK6, respectively. BSJ-02-162 is capable of degrading both CDK4 and CDK6.

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-03-189 - status:Reviewed Edit

Calculated Values
MW: 804.87
Hbond donors: 3
Hbond acceptors: 15
cLogP: 2.27
TPSA: 218.13

SMILES: show

O=C(NCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O

Linker type: Alkane
Incubation time (hours): 4
Cells: Jurkat
IC₅₀: = 69.6 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No

Comments: IC50: 69.6nM/34.6nM for CDK4/CDK6, respectively.

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-03-124 - status:Reviewed Edit

Calculated Values
MW: 889.03
Hbond donors: 3
Hbond acceptors: 15
cLogP: 4.62
TPSA: 218.13

SMILES: show

O=C(NCCCCCCCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O

Linker type: Alkane
Incubation time (hours): 4
Cells: Jurkat
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-04-060 - status:Reviewed Edit

Calculated Values
MW: 703.76
Hbond donors: 2
Hbond acceptors: 13
cLogP: 3.28
TPSA: 179.80

SMILES: show

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3N4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4)=O

Linker type: Other
Incubation time (hours): 4
Cells: Jurkat
IC₅₀: = 130 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No

Comments: IC50: 130nM/45.1nM for CDK4/CDK6 respectively.

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-03-008 - status:Reviewed Edit

Calculated Values
MW: 859.99
Hbond donors: 4
Hbond acceptors: 15
cLogP: 3.87
TPSA: 220.93

SMILES: show

O=C(NCCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4

Linker type: Alkane
Incubation time (hours): 4
Cells: Jurkat
IC₅₀: = 77 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No

Comments: IC50: 77nM/27.6nM for CDK4/CDK6, respectively.

Contributed by: Yangwode Jing

PROTAC (Active) name: YKL-06-102 - status:Reviewed Edit

Calculated Values
MW: 936.04
Hbond donors: 4
Hbond acceptors: 18
cLogP: 2.36
TPSA: 248.62

SMILES: show

O=C(NCCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4

Linker type: PEG
Incubation time (hours): 4
Cells: Jurkat
IC₅₀: = 39 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: Yes, can also degrade IKZF1/3

Comments: IC50: 137nM/39nM for CDK4/CDK6, respectively; Show selective degradation of CDK6 (therefore active for CDK6 and inactive for CDK4).

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-03-007 - status:Reviewed Edit

Calculated Values
MW: 891.99
Hbond donors: 4
Hbond acceptors: 17
cLogP: 2.34
TPSA: 239.39

SMILES: show

O=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4

Linker type: PEG
Incubation time (hours): 4
Cells: Jurkat
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-03-006 - status:Reviewed Edit

Calculated Values
MW: 847.93
Hbond donors: 4
Hbond acceptors: 16
cLogP: 2.32
TPSA: 230.16

SMILES: show

O=C(NCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-03-009 - status:Reviewed Edit

Calculated Values
MW: 1,024.15
Hbond donors: 4
Hbond acceptors: 20
cLogP: 2.39
TPSA: 267.08

SMILES: show

O=C(NCCOCCOCCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-03-135 - status:Reviewed Edit

Calculated Values
MW: 818.89
Hbond donors: 3
Hbond acceptors: 15
cLogP: 2.66
TPSA: 218.13

SMILES: show

O=C(NCCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-03-123 - status:Reviewed Edit

Calculated Values
MW: 937.02
Hbond donors: 3
Hbond acceptors: 18
cLogP: 2.32
TPSA: 245.82

SMILES: show

O=C(NCCOCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O

Linker type: PEG
Incubation time (hours): 4
Cells: Jurkat
IC₅₀: = 37.7 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: Yes
Tested engagement in cells?: No
Off-targets reported?: No

Comments: IC50: 106nM/37.7nM for CDK4/CDK6, respectively. Show selectivity on CDK6 (therefore inactive for CDK4 and active for CDK6).

Contributed by: Yangwode Jing

Target: CDK4 Cyclin-dependent kinase 4 P11802 Homo sapiens

E3 Ligand Binder

E3 ligase: Cereblon
E3 binder: Thalidomide
SMILES: show

O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

Ligand

Ligand Name: Ribociclib
Ligand PDB Id: 6ZZ
PDB with Ligand: 5L2T
SMILES: show

O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C)C

PROTAC (Active) name: BSJ-01-187 - status:Reviewed Edit

Calculated Values
MW: 818.94
Hbond donors: 4
Hbond acceptors: 14
cLogP: 2.92
TPSA: 207.10

SMILES: show

O=C(C1=CC2=CN=C(NC3=NC=C(N4CCN(CCCCNC(CNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O)CC4)C=C3)N=C2N1C8CCCC8)N(C)C

Linker type: Other
Incubation time (hours): 4
Cells: Jurkat
IC₅₀: = 70.8 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: Yes, can also degrade IKZF1/3

Comments: IC50: 70.8nM/52.2nM for CDK4/CDK6, respectively; Show selective degradation of CDK4 (therefore active for CDK4 and inactive for CDK6).

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-01-152 - status:Reviewed Edit

Calculated Values
MW: 761.89
Hbond donors: 3
Hbond acceptors: 13
cLogP: 3.80
TPSA: 178.00

SMILES: show

O=C(C1=CC2=CN=C(N([H])C3=NC=C(N4CCN(CCCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)CC4)C=C3)N=C2N1C8CCCC8)N(C)C

Comments: IC50: 79.7nM/65.5nM for CDK4/CDK6, respectively.

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-01-151 - status:Reviewed Edit

Calculated Values
MW: 821.94
Hbond donors: 3
Hbond acceptors: 15
cLogP: 3.06
TPSA: 196.46

SMILES: show

O=C(C1=CC2=CN=C(NC3=NC=C(N4CCN(CCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)CC4)C=C3)N=C2N1C8CCCC8)N(C)C

Comments: IC50: 175nM/142nM for CDK4/CDK6, respectively.

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-04-132 - status:Reviewed Edit

Calculated Values
MW: 819.92
Hbond donors: 3
Hbond acceptors: 14
cLogP: 2.89
TPSA: 204.30

SMILES: show

O=C(C1=CC2=CN=C(NC3=NC=C(N4CCN(CCCCNC(COC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O)CC4)C=C3)N=C2N1C8CCCC8)N(C)C

Linker type: Other
Incubation time (hours): 4
Cells: Jurkat
IC₅₀: = 50.6 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: Yes
Tested engagement in cells?: No
Off-targets reported?: No

Comments: IC50: 50.6nM/30nM for CDK4/CDK6, respectively; Show selective degradation of CDK4 (therefore active for CDK4 and inactive for CDK6).

Contributed by: Yangwode Jing

E3 Ligand Binder

E3 ligase: Cereblon
E3 binder: Thalidomide
SMILES: show

O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

Ligand

Ligand Name: Palbociclib
Ligand PDB Id: LQQ
PDB with Ligand: 5L2I
SMILES: show

CC(C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O)=O

Representative PROTAC (Active) name: BSJ-02-162 - status:Reviewed Edit

Calculated Values
MW: 832.92
Hbond donors: 3
Hbond acceptors: 15
cLogP: 3.05
TPSA: 218.13

SMILES: show

O=C(NCCCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O

Comments: IC50: 25.7nM/7.57nM for CDK4/CDK6, respectively. BSJ-02-162 is capable of degrading both CDK4 and CDK6.

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-03-189 - status:Reviewed Edit

Calculated Values
MW: 804.87
Hbond donors: 3
Hbond acceptors: 15
cLogP: 2.27
TPSA: 218.13

SMILES: show

O=C(NCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O

Comments: IC50: 69.6nM/34.6nM for CDK4/CDK6, respectively.

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-03-124 - status:Reviewed Edit

Calculated Values
MW: 889.03
Hbond donors: 3
Hbond acceptors: 15
cLogP: 4.62
TPSA: 218.13

SMILES: show

O=C(NCCCCCCCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-04-060 - status:Reviewed Edit

Calculated Values
MW: 703.76
Hbond donors: 2
Hbond acceptors: 13
cLogP: 3.28
TPSA: 179.80

SMILES: show

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3N4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4)=O

Comments: IC50: 130nM/45.1nM for CDK4/CDK6 respectively.

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-03-008 - status:Reviewed Edit

Calculated Values
MW: 859.99
Hbond donors: 4
Hbond acceptors: 15
cLogP: 3.87
TPSA: 220.93

SMILES: show

O=C(NCCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4

Comments: IC50: 77nM/27.6nM for CDK4/CDK6, respectively.

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-03-007 - status:Reviewed Edit

Calculated Values
MW: 891.99
Hbond donors: 4
Hbond acceptors: 17
cLogP: 2.34
TPSA: 239.39

SMILES: show

O=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-03-006 - status:Reviewed Edit

Calculated Values
MW: 847.93
Hbond donors: 4
Hbond acceptors: 16
cLogP: 2.32
TPSA: 230.16

SMILES: show

O=C(NCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-03-135 - status:Reviewed Edit

Calculated Values
MW: 818.89
Hbond donors: 3
Hbond acceptors: 15
cLogP: 2.66
TPSA: 218.13

SMILES: show

O=C(NCCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O

Contributed by: Yangwode Jing

PROTAC (Active) name: BSJ-03-009 - status:Reviewed Edit

Calculated Values
MW: 1,024.15
Hbond donors: 4
Hbond acceptors: 20
cLogP: 2.39
TPSA: 267.08

SMILES: show

O=C(NCCOCCOCCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4

Contributed by: Yangwode Jing