Calculated Values
MW: 1,012.70 Hbond donors: 5 Hbond acceptors: 14 cLogP: 7.43 TPSA: 214.98 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: Alkane Incubation time (hours): 24 Cells: K562 DC50: = 8.5 nM Off-targets reported?: EPHB4, RIPK2, Src, PDGFRβ, BTK Contributed by: Ronen Gabizon
Calculated Values
MW: 956.60 Hbond donors: 5 Hbond acceptors: 14 cLogP: 5.87 TPSA: 214.98 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: Alkane Incubation time (hours): 24 Cells: K562 DC50: = 611 nM Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 1,040.76 Hbond donors: 5 Hbond acceptors: 14 cLogP: 8.21 TPSA: 214.98 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: Alkane Incubation time (hours): 24 Cells: K562 DC50: = 10.1 nM Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 998.68 Hbond donors: 5 Hbond acceptors: 14 cLogP: 7.04 TPSA: 214.98 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: Alkane Incubation time (hours): 24 Cells: K562 DC50: = 17.9 nM Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 1,026.73 Hbond donors: 5 Hbond acceptors: 14 cLogP: 7.82 TPSA: 214.98 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: Alkane Incubation time (hours): 24 Cells: K562 DC50: = 37.9 nM Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 984.65 Hbond donors: 5 Hbond acceptors: 14 cLogP: 6.65 TPSA: 214.98 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: Alkane Incubation time (hours): 24 Cells: K562 DC50: = 34.7 nM Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 970.62 Hbond donors: 5 Hbond acceptors: 14 cLogP: 6.26 TPSA: 214.98 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: Alkane Incubation time (hours): 24 Cells: K562 DC50: = 40.2 nM Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 1,124.92 Hbond donors: 5 Hbond acceptors: 14 cLogP: 10.55 TPSA: 214.98 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCCCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: Alkane Incubation time (hours): 24 Cells: K562 Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 1,176.86 Hbond donors: 5 Hbond acceptors: 19 cLogP: 5.95 TPSA: 261.13 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCOCCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: PEG Incubation time (hours): 24 Cells: K562 Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 1,079.75 Hbond donors: 5 Hbond acceptors: 17 cLogP: 6.48 TPSA: 245.69 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCc3cn(CCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCc4ccc(-c5scnc5C)cc4)C(C)(C)C)nn3)CC2)n1 Linker type: Other Incubation time (hours): 24 Cells: K562 Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 1,027.67 Hbond donors: 6 Hbond acceptors: 15 cLogP: 5.38 TPSA: 244.08 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CNC(=O)CCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: Alkane Incubation time (hours): 24 Cells: K562 Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 1,139.89 Hbond donors: 6 Hbond acceptors: 15 cLogP: 8.50 TPSA: 244.08 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCNC(=O)CCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: Alkane Incubation time (hours): 24 Cells: K562 Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 1,016.65 Hbond donors: 5 Hbond acceptors: 16 cLogP: 5.12 TPSA: 233.44 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)COCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: PEG Incubation time (hours): 24 Cells: K562 Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 1,044.70 Hbond donors: 5 Hbond acceptors: 16 cLogP: 5.90 TPSA: 233.44 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: PEG Incubation time (hours): 24 Cells: K562 Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 1,096.87 Hbond donors: 5 Hbond acceptors: 14 cLogP: 9.77 TPSA: 214.98 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: Alkane Incubation time (hours): 24 Cells: K562 Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 1,158.93 Hbond donors: 5 Hbond acceptors: 17 cLogP: 8.73 TPSA: 225.60 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCCCCCOCCOCCOCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: non-PEG polyether Incubation time (hours): 24 Cells: K562 Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 1,172.92 Hbond donors: 5 Hbond acceptors: 17 cLogP: 8.26 TPSA: 242.67 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCCOCCOCCOCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: non-PEG polyether Incubation time (hours): 24 Cells: K562 Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 1,125.91 Hbond donors: 6 Hbond acceptors: 15 cLogP: 8.97 TPSA: 227.01 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCCCCNC(=O)CCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: Other Incubation time (hours): 24 Cells: K562 Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 1,088.75 Hbond donors: 5 Hbond acceptors: 17 cLogP: 5.92 TPSA: 242.67 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: PEG Incubation time (hours): 24 Cells: K562 Off-targets reported?: No Contributed by: Ronen Gabizon
Calculated Values
MW: 1,132.81 Hbond donors: 5 Hbond acceptors: 18 cLogP: 5.94 TPSA: 251.90 SMILES: show Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1 Linker type: PEG Incubation time (hours): 24 Cells: K562 Off-targets reported?: No Contributed by: Ronen Gabizon |