Calculated Values
MW: 766.83 Hbond donors: 4 Hbond acceptors: 10 cLogP: 3.58 TPSA: 200.39 SMILES: show COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(CCC(=O)NCCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc13)C(=O)N2C Linker type: Alkane Incubation time (hours): 1,2,4,6,16,24 Cells: Big sellection of cacer cell lines Off-targets reported?: No Comments: EC50 of ligand is 0.370 μM for MV4- 11, 3.369 μM for Molm-13. EC50 of PROTAC is 0.012uM for MV4-11, 0.052uM for Molm-13. Contributed by: Daniel Zaidman
Calculated Values
MW: 780.86 Hbond donors: 4 Hbond acceptors: 10 cLogP: 3.97 TPSA: 200.39 SMILES: show COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(CCC(=O)NCCCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc13)C(=O)N2C Linker type: Alkane Incubation time (hours): 1,2,4,6,16,24 Cells: MV4-11, Molm-13 Off-targets reported?: No Comments: EC50 of ligand is 0.370 μM for MV4- 11, 3.369 μM for Molm-13. EC50 of PROTAC is 0.032uM for MV4-11, 0.177uM for Molm-13. Contributed by: Daniel Zaidman
Calculated Values
MW: 752.81 Hbond donors: 4 Hbond acceptors: 10 cLogP: 3.19 TPSA: 200.39 SMILES: show COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(CCC(=O)NCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc13)C(=O)N2C Linker type: Alkane Incubation time (hours): 1,2,4,6,16,24 Cells: MV4-11, Molm-13 Off-targets reported?: No Comments: EC50 of ligand is 0.370 μM for MV4- 11, 3.369 μM for Molm-13. EC50 of PROTAC is 0.025uM for MV4-11, 0.18uM for Molm-13 Contributed by: Daniel Zaidman
Calculated Values
MW: 794.89 Hbond donors: 4 Hbond acceptors: 10 cLogP: 4.36 TPSA: 200.39 SMILES: show COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(CCC(=O)NCCCCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc13)C(=O)N2C Linker type: Alkane Incubation time (hours): 1,2,4,6,16,24 Cells: MV4-11, Molm-13 Off-targets reported?: No Comments: EC50 of ligand is 0.370 μM for MV4- 11, 3.369 μM for Molm-13. EC50 of PROTAC is 3.429uM for MV4-11, >10uM for Molm-13. Contributed by: Daniel Zaidman
Calculated Values
MW: 738.78 Hbond donors: 4 Hbond acceptors: 10 cLogP: 2.80 TPSA: 200.39 SMILES: show COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(CCC(=O)NCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc13)C(=O)N2C Linker type: Alkane Incubation time (hours): 1,2,4,6,16,24 Cells: MV4-11, Molm-13 Off-targets reported?: No Comments: EC50 of ligand is 0.370 μM for MV4- 11, 3.369 μM for Molm-13. EC50 of PROTAC is 1.648uM for MV4-11, >10uM for Molm-13 Contributed by: Daniel Zaidman |
Calculated Values
MW: 766.83 Hbond donors: 4 Hbond acceptors: 10 cLogP: 3.58 TPSA: 200.39 SMILES: show COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(CCC(=O)NCCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc13)C(=O)N2C Linker type: Alkane Incubation time (hours): 1,2,4,6,16,24 Cells: Big sellection of cacer cell lines Off-targets reported?: No Comments: EC50 of ligand is 0.370 μM for MV4- 11, 3.369 μM for Molm-13. EC50 of PROTAC is 0.012uM for MV4-11, 0.052uM for Molm-13. Contributed by: Daniel Zaidman
Calculated Values
MW: 752.81 Hbond donors: 4 Hbond acceptors: 10 cLogP: 3.19 TPSA: 200.39 SMILES: show COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(CCC(=O)NCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc13)C(=O)N2C Linker type: Alkane Incubation time (hours): 1,2,4,6,16,24 Cells: MV4-11, Molm-13 Off-targets reported?: No Comments: EC50 of ligand is 0.370 μM for MV4- 11, 3.369 μM for Molm-13. EC50 of PROTAC is 0.025uM for MV4-11, 0.18uM for Molm-13 Contributed by: Daniel Zaidman
Calculated Values
MW: 780.86 Hbond donors: 4 Hbond acceptors: 10 cLogP: 3.97 TPSA: 200.39 SMILES: show COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(CCC(=O)NCCCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc13)C(=O)N2C Linker type: Alkane Incubation time (hours): 1,2,4,6,16,24 Cells: MV4-11, Molm-13 Off-targets reported?: No Comments: EC50 of ligand is 0.370 μM for MV4- 11, 3.369 μM for Molm-13. EC50 of PROTAC is 0.032uM for MV4-11, 0.177uM for Molm-13. Contributed by: Daniel Zaidman
Calculated Values
MW: 738.78 Hbond donors: 4 Hbond acceptors: 10 cLogP: 2.80 TPSA: 200.39 SMILES: show COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(CCC(=O)NCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc13)C(=O)N2C Linker type: Alkane Incubation time (hours): 1,2,4,6,16,24 Cells: MV4-11, Molm-13 Off-targets reported?: No Comments: EC50 of ligand is 0.370 μM for MV4- 11, 3.369 μM for Molm-13. EC50 of PROTAC is 1.648uM for MV4-11, >10uM for Molm-13 Contributed by: Daniel Zaidman
Calculated Values
MW: 794.89 Hbond donors: 4 Hbond acceptors: 10 cLogP: 4.36 TPSA: 200.39 SMILES: show COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(CCC(=O)NCCCCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc13)C(=O)N2C Linker type: Alkane Incubation time (hours): 1,2,4,6,16,24 Cells: MV4-11, Molm-13 Off-targets reported?: No Comments: EC50 of ligand is 0.370 μM for MV4- 11, 3.369 μM for Molm-13. EC50 of PROTAC is 3.429uM for MV4-11, >10uM for Molm-13. Contributed by: Daniel Zaidman |