PROTACpedia
Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity. Eur J Med Chem. 2020 Apr 15;192:112186. PMID:32145645 DOI:10.1016/j.ejmech.2020.112186
Target: BCL2L1 Bcl-2-like protein 1 Q07817 Homo sapiens
E3 ligase: Cereblon
E3 binder: Pomalidomide
SMILES: show
Ligand Name: ABT-263
Ligand PDB Id: 1XJ
PDB with Ligand: 4QNQ
SMILES: show
Calculated Values
MW: 1,350.02
Hbond donors: 4
Hbond acceptors: 18
cLogP: 9.00
TPSA: 242.40

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
DC50: = 2.5 nM
Tested a non-binding E3 control?: Yes
Tested competition with ligand?: Yes
Tested proteaseome inhibitor?: Yes
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,314.97
Hbond donors: 4
Hbond acceptors: 16
cLogP: 8.94
TPSA: 235.02

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,329.00
Hbond donors: 4
Hbond acceptors: 16
cLogP: 9.33
TPSA: 235.02

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,305.96
Hbond donors: 4
Hbond acceptors: 17
cLogP: 8.98
TPSA: 233.17

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,231.88
Hbond donors: 4
Hbond acceptors: 15
cLogP: 9.34
TPSA: 214.71

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
DC50: = 10.6 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,273.96
Hbond donors: 4
Hbond acceptors: 15
cLogP: 10.51
TPSA: 214.71

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,394.07
Hbond donors: 4
Hbond acceptors: 19
cLogP: 9.01
TPSA: 251.63

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,405.09
Hbond donors: 4
Hbond acceptors: 19
cLogP: 8.68
TPSA: 245.64

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
DC50: = 4.5 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,286.96
Hbond donors: 4
Hbond acceptors: 16
cLogP: 9.02
TPSA: 217.95

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,419.08
Hbond donors: 4
Hbond acceptors: 19
cLogP: 8.21
TPSA: 262.71

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,457.17
Hbond donors: 4
Hbond acceptors: 20
cLogP: 10.72
TPSA: 263.88

SMILES: show
Linker type: Other
Incubation time (hours): 48
Cells: MOLT-4
DC50: = 6.3 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,404.07
Hbond donors: 5
Hbond acceptors: 18
cLogP: 8.37
TPSA: 265.51

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,501.23
Hbond donors: 4
Hbond acceptors: 21
cLogP: 10.74
TPSA: 273.11

SMILES: show
Linker type: Other
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,463.13
Hbond donors: 4
Hbond acceptors: 20
cLogP: 8.22
TPSA: 271.94

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,515.21
Hbond donors: 4
Hbond acceptors: 21
cLogP: 10.26
TPSA: 290.18

SMILES: show
Linker type: Other
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,245.91
Hbond donors: 4
Hbond acceptors: 15
cLogP: 9.73
TPSA: 214.71

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,473.13
Hbond donors: 4
Hbond acceptors: 21
cLogP: 9.09
TPSA: 290.18

SMILES: show
Linker type: Other
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,315.02
Hbond donors: 4
Hbond acceptors: 16
cLogP: 9.80
TPSA: 217.95

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,316.99
Hbond donors: 4
Hbond acceptors: 17
cLogP: 8.65
TPSA: 227.18

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,343.03
Hbond donors: 4
Hbond acceptors: 16
cLogP: 9.72
TPSA: 235.02

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,259.94
Hbond donors: 4
Hbond acceptors: 15
cLogP: 10.12
TPSA: 214.71

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,361.04
Hbond donors: 4
Hbond acceptors: 18
cLogP: 8.67
TPSA: 236.41

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,429.08
Hbond donors: 4
Hbond acceptors: 20
cLogP: 9.08
TPSA: 280.95

SMILES: show
Linker type: Other
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,300.99
Hbond donors: 4
Hbond acceptors: 16
cLogP: 9.41
TPSA: 217.95

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,375.02
Hbond donors: 4
Hbond acceptors: 18
cLogP: 8.19
TPSA: 253.48

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,471.16
Hbond donors: 4
Hbond acceptors: 20
cLogP: 10.25
TPSA: 280.95

SMILES: show
Linker type: Other
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
E3 ligase: VHL
E3 binder: Vh032 Analog
SMILES: show
Ligand Name: ABT-263
Ligand PDB Id: 1XJ
PDB with Ligand: 4QNQ
SMILES: show
Calculated Values
MW: 1,473.33
Hbond donors: 5
Hbond acceptors: 16
cLogP: 13.19
TPSA: 230.76

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
DC50: = 71 nM
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,574.39
Hbond donors: 5
Hbond acceptors: 19
cLogP: 10.87
TPSA: 269.53

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,514.38
Hbond donors: 5
Hbond acceptors: 17
cLogP: 12.48
TPSA: 234.00

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
DC50: = 93 nM
Dmax: ~ 90 %
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,544.36
Hbond donors: 5
Hbond acceptors: 18
cLogP: 11.24
TPSA: 260.30

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,528.41
Hbond donors: 5
Hbond acceptors: 17
cLogP: 12.87
TPSA: 234.00

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,445.27
Hbond donors: 5
Hbond acceptors: 16
cLogP: 12.41
TPSA: 230.76

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,542.39
Hbond donors: 5
Hbond acceptors: 17
cLogP: 12.40
TPSA: 251.07

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
DC50: = 53 nM
Dmax: ~ 100 %
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: Yes
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,546.38
Hbond donors: 5
Hbond acceptors: 19
cLogP: 10.95
TPSA: 252.46

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,556.42
Hbond donors: 5
Hbond acceptors: 17
cLogP: 12.79
TPSA: 251.07

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,459.30
Hbond donors: 5
Hbond acceptors: 16
cLogP: 12.80
TPSA: 230.76

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,501.38
Hbond donors: 5
Hbond acceptors: 16
cLogP: 13.97
TPSA: 230.76

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,528.36
Hbond donors: 5
Hbond acceptors: 17
cLogP: 12.01
TPSA: 251.07

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,579.40
Hbond donors: 5
Hbond acceptors: 20
cLogP: 11.30
TPSA: 267.68

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,491.30
Hbond donors: 5
Hbond acceptors: 18
cLogP: 11.27
TPSA: 249.22

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,502.32
Hbond donors: 5
Hbond acceptors: 18
cLogP: 10.94
TPSA: 243.23

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,542.43
Hbond donors: 5
Hbond acceptors: 17
cLogP: 13.26
TPSA: 234.00

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,560.36
Hbond donors: 5
Hbond acceptors: 19
cLogP: 10.48
TPSA: 269.53

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,500.35
Hbond donors: 5
Hbond acceptors: 17
cLogP: 12.09
TPSA: 234.00

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,487.35
Hbond donors: 5
Hbond acceptors: 16
cLogP: 13.58
TPSA: 230.76

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,515.41
Hbond donors: 5
Hbond acceptors: 16
cLogP: 14.36
TPSA: 230.76

SMILES: show
Linker type: Alkane
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon
Calculated Values
MW: 1,535.35
Hbond donors: 5
Hbond acceptors: 19
cLogP: 11.28
TPSA: 258.45

SMILES: show
Linker type: PEG
Incubation time (hours): 48
Cells: MOLT-4
Tested a non-binding E3 control?: No
Tested competition with ligand?: No
Tested proteaseome inhibitor?: No
Proteomics data available?: No
Tested engagement in cells?: No
Off-targets reported?: No degradation of BCL2
Comments: IC50's are for cell viability assays
Contributed by: Ronen Gabizon