Calculated Values
MW: 1,009.12 Hbond donors: 4 Hbond acceptors: 14 cLogP: 4.52 TPSA: 262.22 SMILES: show CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)OC(CCc1ccc(OC)c(OC)c1)c1cccc(NC(=O)CCC(=O)NCCCCNC(=O)COc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)c1 Linker type: Alkane Incubation time (hours): 18 Cells: MV4;11, 293FT, 293FTCRBN−/− DC50: = 10 nM Dmax: = 50 % Off-targets reported?: No Contributed by: Daniel Zaidman
Calculated Values
MW: 1,141.28 Hbond donors: 4 Hbond acceptors: 17 cLogP: 4.57 TPSA: 289.91 SMILES: show CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)OC(CCc1ccc(OC)c(OC)c1)c1cccc(NC(=O)CCC(=O)NCCCOCCOCCOCCCNC(=O)COc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)c1 Linker type: PEG Incubation time (hours): 18 Cells: MV4;11, 293FT, 293FTCRBN−/− DC50: < 10 nM Dmax: = 60 % Off-targets reported?: No Contributed by: Daniel Zaidman |
Calculated Values
MW: 785.28 Hbond donors: 3 Hbond acceptors: 12 cLogP: 3.68 TPSA: 194.05 SMILES: show Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCCNC(=O)COc1cccc3c1C(=O)N(C1CCC(=O)NC1=O)C3=O)c1nnc(C)n1-2 Linker type: Alkane Incubation time (hours): 1,2,4,8,16,24 Cells: MV4;11, SUM149, SUM159, MOLM13, MM1.SCRBN−/−, MM1.SW IC50: = 20 nM DC50: = 430 nM Dmax: = 95 % Off-targets reported?: BRD2, BRD3, BRD4 Contributed by: Daniel Zaidman |